The Legal, Ethical, and Managerial Concerns of Employee Monitoring Assignment

The Legal, Ethical, and Managerial Concerns of Employee Monitoring - Assignment Example This study declares that as a business, you ought to peruse the representative screening law in the event that you need to comprehend the legalities of worker observing. It states that the boss can screen your workers movements on your workstations. Executives ought to have an Acceptable Use Policy (AUP) set up that is made known to all their representatives and they ought to be made mindful that their workstations and Internet movement are continuously followed. Fundamentally the law states that you can do whatever you need on the grounds that the workstations and the work done on them is your property. An AUP is a composed assention, marked by workers, plotting the terms and states of Internet utilization. It particularly sets out satisfactory utilization, principles of on-line conduct, and access benefits. They can additionally blanket punishments for violations of the strategy, including security violations and vandalism of the framework. From this paper it is clear that anybody utilizing the web could be obliged to sign an AUP, and it ought to be continued document as a legitimate, tying record. Adjusting the true blue need of managers to screen the work environment with deference for singular protection is not troublesome. Corporate ethics refers to the behavior by which a business conforms to its day-to-day dealings with the world. In other terms, it delineates a set of professional ethics which examine moral and ethical problems prevalent in business environments. Corporate ethics is applicable to all the aspects of business conduct. Moreover, it is applicable to the conduct of each and every individual in the organization, as well as the entire organization at large. However, more often than not, research and practice of business ethics has typically taken the view-point of top management.  

Labor law Essay Example | Topics and Well Written Essays - 8750 words

Labor law - Essay Example However, the comparing will be in specific aspects, labor law background in both countries, minimum wage, woman working, and child working. Chapter I Background: The Kingdom of Saudi Arabia and the Unite Sate of America, which are the subject of comparison in this research, had, in various aspects of life such as politics, economy and law. Of course, there is different background in labor law in both countries.In this chapter we will refer to the historical stages of labor law in every state. (2) United States labor lawbackground: Employer took their labor trouble to court almost as soon as American became independent. Each state has its own court, and they often have disagreed with one another about labor cases.(3) Because the First Amendment to the U.S. Constitution protects the freedom of association, the court did not outlaw unions as such. At the beginning of the nineteenth century, a common union tactic was for union members to agree among themselves how much in wage they would accept from their employers; the members also refused to work in the same shop as any other worker who accepted less than union scale. However, the courts held that this tactic was a criminal conspiracy,(4) (will be case as example under minimum wage section below). By the end of the nineteenth century, prosecutions for criminal conspiracy had become ineffective in controlling labor unions. There were two reasons for this change. First, a criminal case was too slow. The work could not be punished until after an indictment was issued and the case had gone to trial. This process took several months, during which the strike or boycott was damaging the employer’s business. Second, jurieswrer increasingly made up of workers, not merely shopkeepers and landowners; andworkers were hesitant to find coworkers guilty of the crime peacefully trying to improve their wage and working condition. Employers, therefore, took their complaints to civil court, and here they found the perfect we apon for fighting unions: the injunction. In the past, the law permitted judges to issue injunctions against unions freely.(5) In 1890, Congress passed the Sherman Antitrust Act in order to control monopolies in business, but the wording of the law was so general that it could applied to labor unions as well. The statute outlawed â€Å" every . . . combination . . . or conspiracy in restraint of trade or commerce among the several states,† Al thought this act was not used against strikes over wages ad hours, it was used to control union organizing. (6) In the infamous DanburyHatters case, the union sought to organize all the fur hat makers of America by boycotting the products of nonunion manufactures. One manufactures sued, arguing that the boycott did diminish trade among the states and awarded hundreds of thousands of dollars of damages payable by the individual workers.(7) Twenty-five years later, in 1914, Congress passed the Clayton Act which stated, â€Å" the labor of a human being is not a commodity or article of commerce† and â€Å" no . . . injunction shall be granted in any case between an employer and employees . . . growing out of a dispute concerning terms or conditions of employment,† Union leaders regarded the Clayton act as a great victory for organized labor. But court turned the victory into defeat by holding congress did not mean to permit boycotts in support of organizing campaigns.

Mix Marketing Plan Essay Example for Free

Mix Marketing Plan Essay The mix marketing plan below is for the 2009 Mitsubishi Outlander compact all wheel drive (AWD) priced under $40,000. This market plan below describes the target market and objectives that are necessary to capture the target market. Furthermore, the plan offers recommendations and some of them methods necessary to promote the Mistubishi Outlander and create awareness of its release on to the market in 2009. Also in the mix market plan is situational analysis that is broken down into four parts. The first part is the current product which describes the brand and core product which in this case is the Mistubishi Outlander. The second part discusses the factors that will affect the price of the Outlander such as competition and demand. The third aspect talks about the current distribution and method in which to distribute the Outlander. This part also talks about the intensity of distribution and the intermediaries used to distribute the Outlander and the factors that influence the distribution such as storage and transport of the Outlanders from point of manufacture to the point of sale. The fourth situational analysis aspect is the promotional theme and the elements integrated in the promotion mix. The theme is that of cross between an all wheel drive and a sports utility vehicles that is both excellent as urban cruiser as well as an off road medium sized vehicle. The recommended target market for the Outlander is mainly the medium sized family that enjoys occasional family trips out of urban localities. The age group of the consumer interested in purchasing the Mistubishi outlander will range between 25 to the 50 years of age. This demographic will most likely reside in the upper middle class suburbs of Perth. The main aim of this mix marketing plan is to make consumers familiarise themselves with the Outlander, promote the outlander to all intermediaries through workshops and seminars. Increase volume of promotional content of the Outlander through media channels such as online advertising, email promotions, radio and television advertisements. The customers are made of the Mistubishi Diamond Advantage. Situational Analysis Current Product: The Mistubishi outlander is a cross over all wheel drive (AWD) from the product line of the Mitsubishi Motor Company. The Outlander is a shopping type of consumer product that is in its Introduction stage. It is a compact AWD that can be driven in urban areas as well as off road. However, the Outlander does not have Electronic Stability control system (ESP) but does come with an expandable row making it a seven seater and a bisected rear door for easy accesses to the rear cabin space. The ESP can always be added on to the future cars by adopting the system that is used in other Mitsubishi models. Current Pricing: The current influences on the price of the Outlander include demand, competition and other external factors such as economic situation and good value pricing (Kotler et al.2007, 350). The Mistubishi Outlander is in the monopolistic market as they are many sellers offering alternatives (Pierre and Toulemonde 2009, 1347) .AWDs such as the Toyota Rav Four and Nissan Extrail. The pricing objective of the Outlander is based on the price of competitor’s model of SUVs and the mix of models of the Outlander offered by Mistubishi under $40000. Current Distribution: The outlander is distributed indirectly from the factory through intermediaries such as the dealerships. Intermediaries provide a link between the manufacturer and consumer (Ansari, Mela and Neslin 2008, 60).The dealers include organisations that specialise in Mistubishi vehicle sales and services. Distribution of the outlander is selective for easier negotiations and one tone customer interaction. Some of the factors that may affect distribution include transport and Storage of the Mistubishi outlanders from the point of manufacture to the point of sale. Current Promotion: The main objective is to get the consumers familiarise themselves with the new Mitsubishi Outlander. The theme is that of a sports utility vehicles that is both excellent as urban cruiser as well as an off road medium sized vehicle. Advertising, direct Marketing sales promotions are some of the methods used to show to the customer the sporting side as well as its ability to use as urban vehicle through events such as the Dakar Rally. Recommended Target Market The recommended target market for the Outlander is mainly the medium sized family that enjoys occasional family trips out of urban localities. The age group of the consumer interested in purchasing the Mistubishi outlander will range between 25 to the 50 years of age. The consumer will most likely come from middle class urban setting and enjoys showing off the off-road capabilities of their car while being a comfortable and stylish car to drive around town. This target market has the most potential because the outlander is an urban sports vehicle that has an extra row of seats to accommodate a total of 7 passengers as compared to its rivals on the market within the same price range. The outlander also comes with a lot more standard features as compared to its rivals on the market. Some off the unique features include interchangeable all wheel drive that can be selected at any driving speed. The outlander also has a compact third row seat that does not compromise boot space and is still accommodate two extra passengers. Recommended Marketing Objective:’ In order to keep the Mitsubishi Outlander ahead of the other brand of cross over AWDs on the market, some short term marketing strategies will have to be put in place. These include : Making the consumers familiarise themselves with the Outlander, promote the outlander to all intermediaries through workshops and seminars. Increase volume of promotional content of the Outlander through media channels such as online advertising, email promotions, radio and television advertisements. Another approach would be to promote the Outlander through competitions, sponsorships of sporting activities and discounted sales to the first few customers. Boost the appeal of the outlander by offering membership to outlander car club through the Mitsubishi Diamond Advantage as part of a package deal for the purchase of an Outlander which is a 10 year 160 000 km drive train warranty and the 5 year unlimited 130 000 km warrant plus roadside assistance. Product recommendations Since the product at hand is a motor vehicle, the product packaging will not be required however all other aspects of the product such as branding extensions will be taken into consideration. The product at focus is the Outlander which comes from the product mix of Mitsubishi motor company; it only has one product lines with a narrow width. Therefore, only the depth of the product mix can be explored to give the consumer a variety to pick from the range of Outlanders available. The Mitsubishi Outlander is offered in three models namely the LS, XLS and the optional XLS Luxury pack. The Three models offered come with different options and at a varied price range depending on the added extras. However, the base model still has a starting base price of $31,990 that is fixed depending on whether the customer chooses to add extras to the vehicle. The base model of the outlander is the Ls which comes with 2.4 litre 4 cylinder MIVEC engine, driver and passenger side airbags. The LS models also comes with All Wheel Control 4WD (AWC), air condition, cruise control, Keyless entry, power windows, a steering wheel with audio controls, Stability and traction control. The XLS model has added on features that the LS does not have such as: Continuously variable automatic transmission (CVT), INVECS Smart Logic and 6 steps Sports Mode, Paddle gear shifts, Smart Key, Bluetooth voice activated phone connectivity, chrome grill surround, 18† alloy Wheels, Reverse parking sensors, Adaptive Front Lighting system, High intensity Discharge Head Lamps (HID), Fog Lamps and Privacy Glass. The third model of the outlanders is the optional XLS Luxury pack. This model has additional feature to the XLS model. These key features include 18† 7 spoke wheels, chrome exterior highlights, electric sunroof, Rockford Fosgate premium sound system with 9 speakers, Rear entertainment system, Mitsubishi Multi Communication system (MMCS) including satellite navigation and reverse camera, automatic dusk sensing head lamps, automatic rain sensing wipers, leather seats facings, power driver seat and heated front seat. Pricing recommendations The pricing recommendations for the Mitsubishi Outlander will include the product line price, product bundle pricing and optional –product pricing. The product line price in this situation is considered because the product line width is narrow and limited to the Outlander models namely the LS, XLS and The Optional XLS model. Therefore, the pricing of the models will also be affected by what model is being sold through the intermediaries to the consumer. The purpose is to insure profit maximisation of the base model LS by mass distribution to the companies and leasing companies. With the LS having least of the features, making it the level entry model of the Outlander models. The second thing that is considered when it comes to product line pricing is the optional product line pricing. This will help increase the Mitsubishi profits from the sale optional accessories that can be added to the features of the Outlander’s base model the LS. Some of the features intended for the target market include, 18† alloy wheels, reverse parking sensors, High intensity Discharge Head Lamps (HID), Fog Lamps and Privacy Glass, electric sunroof, chrome exterior highlights, Rockford Fosgate premium sound system with 9 speakers and rear entertainment system. The perceived value of the extras is reasonable priced as all extras added on to the Outlander models come with a 5 year 130000 km warranty. The last recommendation for product line price is product bundle pricing, where the Outlander models are sold as bundles. This can be achieved when either selling the Outlanders with just the basic features at a much lower price as compared to the base models. The target market is leasing companies, private and government organisations in bulk. Furthermore, pricing adjustments can be made to increase sales such as discounts on bulk buys and end of financial year sales and further discounts for early or cash payments. The Outlander is not new to the car market, therefore the new product pricing strategy that is recommended is the market –penetrating pricing strategy to attract a large number of buyers and share market as it’s a medium quality and medium price product. Distribution recommendations The recommend method of distribution channel is using indirect channel through intermediaries such as agents, retailers and wholesalers. The intermediaries act as the third party link between the Mitsubishi and the consumers. The involvement of intermediaries allows the Mitsubishi to reach geographical dispersed groups and avoid direct investment. The Mitsubishi car company does not have to have a direct involvement with credit facilities or have local knowledge of customers. Furthermore, Mitsubishi can earn a greater return by investing in their main business rather than in direct marketing. The intermediary can deal directly with the customers at a more efficient and effective level often provide a supplier or manufacturer more returns than the manufacture can achieve on their own. This due to the amounts of contacts they have in the industry, experience, specialisation and scale of operation. Therefore, the channel of distribution is the retailer channel. That is from the manufacturer to the retailer then the consumer. The retailers sell the Outlander directly to the customers by so doing making the level of distribution intensity selective. This enables Mitsubishi deal directly with a few selected dealers that sale and provided services of goods manufactured by the Mitsubishi motor company. Channel conflict is minimised by dealing directly with intermediaries who are responsible for delivery and sale of the Outlanders. By doing so the conflict most likely to arise is between the Mitsubishi and the exclusive distributors. Promotion recommendations Before any promotional recommendations can be made in terms of promotions for the Mitsubishi Outlander, a number of things have to be considered. The major decision that has to be made includes objective setting, advertisement budget, advertising strategy and evaluation. When it comes to setting the budget, the product life cycle (PLC) has to be taken into consideration. From the introduction of the new Outlander where light advertising and pre introduction publicity to heavy advertising and awareness. This is the growth stage where brand loyalty and personal selling are greatly enforced. The maturity stage involves the decrease in sales promotion personal selling and the decline stage is where advertisements and promotions reduce with limited sales. These stages will determine the over head for the budget. The other promotional recommendation is the public relations mix and media selection through which to do the advertising. The media strategy includes selecting the media format. For example the newspaper has mass audience following and is good for targeting a specific audience via quick distribution. Magazines are mainly for segmented audience however, the information is intensive and highly visual. Television combines both sight and sound however most ads are ignored and only good when trying to build brand awareness and if there are adequate financial resources for the advertisement. However, radio has immediate delivery and good for stimulate impulse purchasing, cheap to advertise but does not have a visual impact. Last, there is outdoor advertising at the car dealership on the lawns where there is great traffic flow. Sales promotion is also another way to attract new customers to the Mistubishi Outlander. This also helps retain loyal Outlander customers and also regain past purchasers who have no longer purchase Mistubishi Outlander. This can be achieved through cash – back offers, competitions, premium offers offering more test drives of the Outlander models. Promotions can also be done through personal selling and interpersonal communication with target consumer groups. This involves two way communications between sales people and individual customers. The sales people are the link between the Mistubishi motor company and the customers and vice-versa. Another method that can be used is direct communication using electronic network tools and technologies via the internet. Telemarketing, telesales other forms of direct marketing that can be used to promote the sale of the Outlander. Other unconventional methods of promotions that can be used are: viral marketing by passing on information to others creating exponential growth in the messages response. Viral communications incurs very little expenses however there is limited control over receipt of the messages. The forms of passing information and advertising that are becoming popular blogs. Blogging is one method of creating hype for a product with no costs and also be able to facilitate communication between organisations and their stakeholders. Endorsements by celebrities via paid verbal testimonials or physical association with a brand. The upside is that advertising air time is practically free and the public is often not informed whether the celebrity is renumerated by the company. Conclusion. The above mix marketing plan is designed for the 2009 Mitsubishi Outlander all wheel drive AWDs. The mix market plan describes the target audience and recommends ways in which to capture the intended market. The plan has further recommendation on how to create awareness for the 2009 Outlander and methods of price, distribution and promotion. The mix market plan also has situational analysis that breaks down the recommended mix marketing strategy into four aspects that current product, current pricing, current distribution and the current promotion. The mix market plan also explains the chosen theme that is a cross between an all wheel drive and sports utility vehicle that is also excellent as an urban cruiser. Furthermore, there is emphasis on the outlander’s unique features for vehicles whose base price is under $40,000.

Fe-AZT and Pd-AZT Synthesis and Effects

Fe-AZT and Pd-AZT Synthesis and Effects Synthesis and Effects of Fe-AZT and Pd-AZT on Viability of Human Hepatocytes and Hepatocellular Carcinoma Cells Submitted by: Anna Harutyunyan Introduction Cancer is one of the major causes of mortality in the world. In 2015, according to the National Cancer Institute, over 1.6 million new cases of cancer were reported in the United States. The estimated cancer deaths for the year of 2015 were over 500,000. According to the National Cancer Institute projections, in 2016 an estimated 1.7 million new cases of cancer were diagnosed in the United States and 595,690 people will die from the disease (National Cancer Institute). Although new cancer treatments and therapies are designed and implemented every year, cancer is still the number two cause of mortality in the United States, therefore developing and testing new effective anticancer agents is crucial. Hepatocellular carcinoma (HCC) is one of the deadliest forms of cancers (Venook et al., 2010). The overall 5-year survival rate of HCC is less than 17%, making HCC the fastest rising cause of cancer related death in the United States (American Cancer Society 2016; Mittal and El-Serag, 2013). The annual age-adjusted incidence rates of HCC increased from 1.4 per 100,000 individuals in 1975-77 to 4.8 per 100,000 in 2005-07. An estimated 39,230 new cases of liver cancer (including intrahepatic bile duct cancers) were expected to occur in the US during 2016, approximately three-fourths of which would be hepatocellular carcinoma. An estimated 27,170 liver cancer deaths were expected in 2016 (American Cancer Society 2016). In 80-90% cases HHC occurs with and after cirrhosis. HCCs major risk factors are Hepatitis B and C viruses, cirrhosis, non-alcoholic fatty liver disease (NAFLD), overconsumption of alcohol and exposure to other carcinogenic substances (Mittal and El-Serag, 2013). Liver ca ncer is the sixth most common neoplasm and the third leading cause of cancer-related deaths, accounting for approximately 600,000 deaths annually (Venook et al., 2010). Because of early metastasis and progression, HCCs treatment is difficult, and traditional chemotherapy has shown limited success (Sabokrough et al, 2014). A research study published in 2015 suggested that an organometallic complex of platinum (II) azidothymidine (Pt (II)-AZT) has an antitumor effect on rat hepatocellular carcinoma cells. It was shown that this complex was significantly more effective in tumor suppression than the AZT without platinum (Sabokrough et al., 2014). Several organometallic complexes of AZT (with Zinc, Cobalt, Copper and Iron) were synthesized and characterized previously. The Iron complex of AZT (Fe-AZT) was shown to be the most stable (Shirvastav et al.) and have antimicrobial activity against 4 groups of bacteria. Electron rich ligands like AZT effectively bind and interact with metal ions producing metallodrugs which offer promising therapeutic application in terms of combating the drug-resistant strains of pathogens. It is also logical that a metal ion can influence the biological activity and therapeutic efficacy of the bio-molecule they bind (Shirvastav et al.) Thus it is useful to investigate the effect of a metal ion on the efficacy and mode of action of AZT in suppressing malignant cells and inducing apoptosis. To date, no research has been published regarding synthesis of Pd-AZT the inhibitory effect of both Fe-AZT and Pd-AZT on malignant cells. The aim of this research project is to synthesize Fe-AZT and Pd-AZT, confirm their structure and molecular mass and test their effects on viability of human hepatocellular carcinoma cells and normal human hepatocytes. Background Normal cell cycle In order to understand the biology of cancer it is crucial to understand the cell cycle of normal cells and cancerous cells. All cells in a given organism are under strict control of multiple regulatory agents, such as RB or p53 that control cell growth and keep the proliferative index stable. If there is a need for the cell to divide, the proliferative genes will turn on, or the suppressor genes that keep proliferation from occurring will be shut down, which will result in cell division (Hardin et al., 2014). The normal cell cycle consists of the following phases: G1, S, G2, M. During the G1 phase duplication of organelles, membrane systems and other important components happens. There is an important checkpoint at the end of this phase referred to as the restriction checkpoint, which verifies that DNA synthesis was successful and no errors have been detected. Next is the S phase during which the cell duplicates each chromosome. During the G2 the rest of the components that were not synthesized in the G1 phase are synthesized. A checkpoint after this phase makes sure the cell is ready to divide, and no errors in chromosome duplication were made. Mitosis is the next phase, when the cell physically divides (cytokinesis) making two identical daughter cells. A checkpoint during this phase checks if both of the daughter cells received the correct number of chromosomes. After division, the cell may remain in its silent G0 phase, when it does not divide, but continues to function. If any errors are detected on any of the checkpoints, the cell cycle is put on hold and the cell will undergo apoptosis. This process is governed my many enzymes and complexes, and theoretically, malfunction of any of these enzymes may result in uncontrolled cell division/proliferation. This can be the onset of carcinogenesis. Figure 1. The cell cycle phases with their checkpoints. Cancer cell cycle It is important to note that the normal cell cycle is under control of thousands of regulatory elements that are coded for by different genes. If mutations occur in the genes that code for the key elements keeping cell proliferation at bay, one level of control over the cell cycle is lost. There are cell signaling mechanisms through which immune cells detect faulty cells, send them death signals and the faulty cell undergoes apoptosis. It takes more than one mutation for a normal cell to start behaving like a cancer cell. Usually it is either the loss of the function of suppressor genes, or overexpression of proliferative genes that result in uncontrolled cell proliferation. When the cell becomes malignant, it loses the ability to respond to death signals, thus does not undergo apoptosis. The malignant cell cycle is slower than the normal cell cycle, however, since the cancer cells keep dividing and do not die, their number grows exponentially resulting in tumors (Weinberg, 2014). There is distinct cytological difference between normal and cancer cells (Figure 2). A normal cell has a smaller, regularly shaped nucleus, a low nucleus/cytoplasm ratio, is well differentiated and has well defined borders. Cancer cells have larger, irregularly shaped nucleus, high nucleus/cy toplasm ratio, are less differentiated and have irregular borders. In contract with normal cells that adhere to each other, cancer cells are less adhesive and break away from each other (Weinberg, 2014). Figure 2. The comparison of the cytology of normal cells and cancer cells. Azidothymidine (AZT), Fe(III)AZT, Pd(II)AZT Azidothymidine (AZT, Zidovudine) is a thymidine derivative in which the 3-hydroxy group is replaced by an azido group (Figure 3). It has been shown to have antitumor effects on different animal carcinoma cells both in vitro and in vivo through inhibition of telomerase activity and by causing cell cycle arrest (Gomez et al., 2012; Hadizadeh et al., 2014, Cooper and Lovett, 2011; Matteucci et al., 2015). Figure 3. Thymidine (left), Azidothymidine (right). Since cancer cells have higher proliferation rate than normal cells, their thymidine turnover rate is higher, which could contribute to their increased sensitivity to AZT. Several studies conducted by Fang et al., have shown that a hepatocellular carcinoma cell line (HepG2) is significantly more sensitive to AZT toxicity as compared to the normal hepatocyte (THLE2) sensitivity (Fang et al., 2014; Fang and Beland, 2009). The current hypothesis on how AZT affects the cell suggests that AZT is phosphorylated intracellularly yielding AZT-triphosphate and AZT-monophosphate. The AZT-monophosphate can be incorporated into the DNA structure instead of thymidine due to its similar molecular structure and shape. However, in contrast with thymidine, AZT lacks the 3 hydroxyl group which is the group that forms phosphodiester bonds between nucleotides in the DNA backbone structure. This means, wherever the AZT phosphate is incorporated in one of the DNA strands during DNA replication, the elongat ion of that strand halts (Figure 4). This is one of the mechanisms through which AZT causes damage to DNA (Fang et al, 2014). The commercial name of AZT is Zidovudine, and it is the basis of AIDS treatments. AZT blocks the replication of HIV-1 virus by competitively inhibiting the viral reverse transcriptase (RT). In other words, HIV RT prefers AZT to normal nucleotides. As described above, AZT is phosphorylated to AZT-triphosphate and is incorporated into viral DNA, halting nucleotide chain elongation. It is also known that AZT-triphosphate can be incorporated into eukaryotic DNA, although its affinity for DNA polymerases is lower than that for RT (Gomez et al, 2012). It was shown that Pt(II)-AZT is more effective in suppressing cancer cells than AZT, thus it has been suggested that having a transition metal bound to the central nitrogen atom of the azido group increases the complexs affinity for G-C and A-T base pairs and the P-backbone of DNA (Das and Pitre, 2007; Sabokrouh et al, 2015). Materials and Methods Fe-AZT and Pd-AZT synthesis To carry out the synthesis of Pd and Fe complexes, solid AZT and a standard ion solution of each metal (iron nitrate nonahydrate (Fe(NO3)3 ·9H2O and palladium chloride (PdCl2)) will be purchased from Sigma Aldrich (St. Louis, MO). Synthesis will be performed according to the protocol by Das and Pitre (2007). A 1:1 molar ratio of aqueous solution of AZT and metal ion will be refluxed for 3 hours. The volume of the reaction mixture will be reduced by 75% in order for the complex to precipitate. The solid product will be vacuum filtered, washed twice with ice-cold water, recrystallized and air-dried overnight. Infrared absorbance spectra will recorded for the AZT, Fe-AZT and Pd-AZT complexes. In the experiment conducted by Das and Pitre (2007) the comparison of IR spectra of pure AZT and its complex with Fe, the spectrum indicated a shift in bands from 2170 to 2150 cm-1 due to complexation through N atom of azido group. A similar band shift in the IR spectrum of Fe-AZT and Pd-AZT is expected. A Matrix Assisted Laser Ioniation/Distortion Time-of-Flight (MALDI TOF) mass spectrometry analysis will be performed for the Fe-AZT and Pd-AZT to determine the molar mass and the stoichiometry of the complexes. The matrix for analysis will be composed of 1:1 saturated Anthranilic Acid and Nicotinic Acid (Sigma Aldrich, St. Louis, MO). The samples and matrix will be dissolved in 45% acetonitrile: 55% water (van Kampen et al., 2004). Cell cultures HepG2, THLE2. Liver carcinoma cell line HepG2 and normal human liver cell line THLE2 will be obtained from American Type Culture Collection (Manassas, VA). The standard protocol recommended by ATCC will be used for establishing and maintaining hepatic cell lines. The cell lines will be plated at a density of 5 x 103 cells/cm2. HepG2 cells will be cultured in DMEM with 10% fetal bovine serum and antibiotics (penn/strep). THLE2 cells will be cultured in LHC-8 medium with 70ng/ml phosphoethanolamine, 5ng/ml epidermal growth factor, 10% fetal bovine serum and antibiotics (Fang et al., 2009). After ensuring sufficient cell growth and several passages of each cell line, the two cell lines will be divided into 4 groups each: control (no treatment) and treated with each drug: AZT, Fe-AZT and Pd-AZT (Table 1). Table 1. The experimental setup of the control and experimental groups of cells. Control 1 (C1) THLE2 cell line (no treatment) Control 2 (C2) HepG2 cell line (no treatment) Experimental 1 (E1) THLE2 cell line+AZT Experimental 2 (E2) HepG2 cell line+AZT Experimental 3 (E3) THLE2 cell line+Fe-AZT Experimental 4 (E4) HepG2 cell line+Fe-AZT Experimental 5 (E5) THLE2 cell line+Pd-AZT Experimental 6 (E6) HepG2 cell line+Pd-AZT The cells in the treated groups will be further categorized by the concentrations of the drug. HepG2 cells will be incubated with 2, 20 or 100  µM aqueous solution of AZT, Fe-AZT or Pd-AZT for 14 days. THLE2 cells will be incubated with 50, 500 or 2500  µM aqueous solution of AZT, Fe-AZT or Pd-AZT for 14 days. Each group of cells will be seeded at 5 x 103 cells/cm2 density in 6-well plates. The cells will be passaged weekly during the two-week treatment period. The dosage and incubation time were chosen based on a similar study (Fang et al., 2013; Matteucci et al., 2015; Sabokrouh et al., 2015). Cell viability assay After 14-day treatment period, 103 106 cells from each group will be seeded in a 96-well plate, incubated for 4 hours, and treated with MTT reagent, followed by a 8-12 hours incubation at 37 °C. After the incubation with MTT, when the cells have metabolized the yellow tetrazolium dye (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) to purple formazan, the cells will be treated by a detergent to release the formazan into the solution, and the absorbance will be measured at 570nm using an ELIZA reader. The number of metabolically active cells will be determined using a previously made calibration curve. The statistical differences will be calculated using a Two-Way ANOVA and Tukeys Post-Hoc Test. Anticipated outcomes. The expected mass-to-charge ratio from mass spectrometry analysis of Fe-AZT complex is 323.1, that of Pd-AZT is 373.6. Based on the published literature and the adopted hypothesis, all three drugs are expected to decrease cell viability. The concentration of either drug should have positive correlation with decrease in cell viability. Based on previous observations, it is expected that the HepG2 cells will be significantly more sensitive to both complexes, thus will be significantly less viable after the treatment compared to the THLE-2 cells. Study Participants and Timeline Anna Harutyunyan is the primary author of this study. She is currently a senior biology and chemistry major at Wilson College. This project will serve as Annas senior research project. She will conduct the research and present the results with the supervision of her advisors Dr. Deborah S. Austin (Sponsoring PAS member) and Dr. M. Dana Harriger (PAS Member). The research study began in September 2016 and will be completed by April 2017. Annas research findings will be analyzed and written as her senior thesis. Anna will also present her findings at the 2017 Pennsylvania Academy of Science meeting and at the Wilson College research colloquium. Budget Item Price MTT Assay Kit (ThermoFisher) $235.00 Zidovudine (Sigma) $124.00 LHC-8 medium (Gibco) $140.00 Total $499.00 Facilities and Equipment The MALDI TOF mass spectrophotometer will be provided by Pennsylvania State College of Medicine Mass Spectrometry Facility under supervision of Bruce Stanley, PhD. All materials, other instruments, and equipment not listed, including cell culture media and supplies, will be provided by the Department of Physical and Life Science of Wilson College. References       American Cancer Society. Cancer Facts Figures 2016. Atlanta: American Cancer Society; 2016. Bilsland AE, Stevenson K, Liu Y, Hoare S, Cairney CJ, Roffey J, et al. (2014) Mathematical Model of a Telomerase Transcriptional Regulatory Network Developed by Cell-Based Screening: Analysis of Inhibitor Effects and Telomerase Expression Mechanisms. PLoS Comput Biol 10(2): e1003448. doi:10.1371/journal.pcbi.1003448 BIOL2060 Cell Cycle [Photograph found in Department of Biology Memorial University of Newfoundland]. (2015). In Hardin Bertoni (Authors). Retrieved March 30, 2016, from http://www.mun.ca/biology/desmid/brian/BIOL2060/BIOL2060-19/CB19.html Chen, Yi-Bin. Liver Cancer Hepatocellular Carcinoma: MedlinePlus Medical Encyclopedia. U.S National Library of Medicine. U.S. National Library of Medicine, 1 Aug. 2015. Web. 10 Apr. 2016. Cooper, D. L., Lovett, S. T. (2011). Toxicity and tolerance mechanisms for azidothymidine, a replication gap-promoting agent, in Escherichia coli. DNA Repair, 10(3), 260-270. http://doi.org/10.1016/j.dnarep.2010.11.007 Das, R., Pitre, K. S. (september 2007). Bioinorganic studies on Fe (II)- zidovudine (azt) complex. Indian Journal of Chemical Technology, 14, 526-528. Retrieved February 20, 2016. Fang, J.-L., Beland, F. A. (2009). Long-Term Exposure to Zidovudine Delays Cell Cycle Progression, Induces Apoptosis, and Decreases Telomerase Activity in Human Hepatocytes. Toxicological Sciences, 111(1), 120-130. http://doi.org/10.1093/toxsci/kfp136 Fang, J., Han, T., Wu, Q., Beland, F., Chang, C., Guo, L., Fuscoe, J. (2014). Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Archives Of Toxicology, 88(3), 609-623. doi:10.1007/s00204-013-1169-3 Gomez, D. E., Armando, R. G., Alonso, D. F. (2012). AZT as a telomerase inhibitor. Frontiers in Oncology, 2, 113th ser. Retrieved March 11, 2016, from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434370/ Hadizadeh, S., Najafzadeh, N., Mazani, M., Amani, M., Mansouri-Torshizi, H., Niapour, A. (2014). Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines. Biochemistry Research International, 1-9.doi:10.1155/2014/813457 Hardin, J., Bertoni, G., Kleinsmith, L. J., Becker, W. M. (2014). Beckers world of the cell (8th ed.). Boston: Benjamin Cummings. Harrington, J. A., Reardon, J. E., Spector, T. (1993). 3-azido-3-deoxythymidine (AZT) monophosphate: an inhibitor of exonucleolytic repair of AZT-terminated DNA. Antimicrobial Agents and Chemotherapy, 37(4), 918-920. van Kampen Jeroen J.A., Fraaij Pieter L.A., Vishal Hira, van Rossum Annemarie M.C., Hartwig, Nico G., de Groot Ronald, Luider Theo M.. A new method for analysis of AZT- triphosphate and nucleotide-triphosphates. Biochemical and Biophysical Research Communications, Volume 316, Issue 3, 9 April 2004, 151-159] Matteucci, C., Minutolo, A., Marino-Merlo, F., Grelli, S., Frezza, C., Mastino, A., Macchi, B. (2015). Characterization of the enhanced apoptotic response to azidothymidine by pharmacological inhibition of NF-kB. Life Sciences, 127, 90-97. doi:10.1016/j.lfs.2015.01.038 Mittal, S., El-Serag, H. B. (2013). Epidemiology of HCC: Consider the Population. Journal ofClinical Gastroenterology, 47(0), S2-S6.http://doi.org/10.1097/MCG.0b013e3182872f29 National Cancer Institute. (n.d.). Surveillance, Epidemiology, and End Results Program. Retrieved February 16, 2016, from http://seer.cancer.gov/statfacts/html/all.html Neto, V. (2013, January). AZT action [Photograph found in Organic Chemistry]. Retrieved April 1, 2016, from http://wwwblogvine.blogspot.com/2013/01/azt-was-originally-intendedto- treat.html (Originally photographed 2013, January 20) Normal And Cancer Cells Structure [Photograph found in Cells or Tissue Abnormal Cells or Tissue Cells or Tissue Normal Cells or Tissue Historical Graphics, National Cancer Institute]. (2001, January 1). In P. Kenny (Illustrator). Retrieved April 1, 2016, from https://visualsonline.cancer.gov/details.cfm?imageid=2512 (Originally illustrated 1990, April) Pichard, L., Raulet, E., Fabre, G., Ferrini, J. B., Ourlin, J. C., Maurel, P. (2006, February). Human hepatocyte culture. Retrieved March 11, 2016, from https://www.researchgate.net/publication/7063976_Human_hepatocyte_culture Sabokrouh, A., Vaisi-Raygani, A., Goodarzi, M. T., Khatami, S., Taghizadeh-jahed, M., Shahabadi, N., à ¢Ã¢â€š ¬Ã‚ ¦ Shakiba, Y. (2015). Comparison between Platinum-Azidothymidine and Azidothymidine Effects on Bcl-2 and Telomerase Gene Expression in Rats with Hepatocellular Carcinoma. Avicenna Journal of Medical Biotechnology, 7(2), 50-56. Sabokrouh, A., Goodarzi, M. T., Vaisi-Raygani, A., Khatami, S., Taghizadeh-Jahed, M. (2014). Effects of Treatment with Platinum Azidothymidine and Azidothymidine on Telomerase Activity and Bcl-2 Concentration in Hepatocellular Carcinoma-Induced Rats. Avicenna Journal Of Medical Biotechnology, 6(4), 200-209. Telomere Shortening Determines the Proliferative Lifespan of Human Diploid Fibroblasts. 2001. Nature Reviews. By Nicole F. Mathon and Alison C. Lloyd. Web. 21 Mar. 2016. ThermoFisher Scientific. (n.d.). MRNA Extraction. Retrieved March 11, 2016, from https://www.thermofisher.com/us/en/home/life-science/dna-rna-purification-analysis/rna- extraction/rna-types/mrna-extraction.html Venook, A. P., Papandreou, C., Furuse, J., De Guevara, L. L. (2010). The Incidence and Epidemiology of Hepatocellular Carcinoma: A Global and Regional Persprective. The Oncologist, 4(15), 5-13. Retrieved March 11, 2016, from http://theoncologist.alphamedpress.org/content/15/suppl_4/5.long Weinberg, Robert A. The Biology of Cancer. 2nd ed. New York, NY: Garland Science, 2014. Print.

Five Equations That Changed The World :: science

Five Equations That Changed The World â€Å"He [Isaac Newton] sought out secluded areas, where he would sit for hours at a time, not so much to observe the natural world as to immerse himself in it† Sir Isaac Newton was a man who would keep to himself. If not for that quality he may not have made the discoveries that he did. He would often sit in the garden for hours on end just thinking and formulating his ideas about the universe. In fact, that is the very place where the ideas of gravity and centrifugal force first came to him. He noticed an apple fall, and wondered why the apple fell to the earth but the moon didn’t. His discoveries about gravity led to his equation â€Å"E = G x M x m x d^2†, which means â€Å"the force of gravity is equal to the gravitational constant multiplied by the two masses involved divided by the square of the distance between them. This equation told scientists in NASA how to escape gravity and leave the earth to go to the moon. â€Å"In other words, there appeared to be a trade-off between pressure and speed: The smaller the speed, the greater the pressure, or the greater the speed, the smaller the pressure† This is a great discovery of Bernoulli. It seems to make sense when we apply it to blood vessels. Where the blood moves faster, the more it pushes forward, the less it pushes on the walls. A later more ingenious application for this idea is flying. The airplane was invented after Bernoulli but not due to him. The airplane and Bernoulli’s equation â€Å"P + p x  ½v^2 = CONSTANT†, were not connected until a Russian scientist by the name of Nikolai Zhukovsky made an excellent observation. He noticed that the tops of the wings of the plane were rounded. When he tested a plane in a wind tunnel, he noticed that the wings created two jet streams, an upper and a lower. The upper jet stream was narrower than the lower. Air is considered a fluid, so therefore the jet stream can be viewed as a river. According to Leonardo DA Vinci’s â€Å"Law of Continuity†, which says â€Å"A river of uniform depth will have a more rapid flow at the narrower section than at the wider†, the upper jet stream is faster than the lower. This is an amazing discovery on Zhukovsky; he had discovered how airplanes flew.

My Room :: essays research papers

My First Bedroom   Ã‚  Ã‚  Ã‚  Ã‚  All my life I had shared a bedroom with my siblings. First, I had to share a bedroom with my brother, because we lived in a two-bedroom apartment. A few years later my sister was born. By then, we have moved into a three-bedroom apartment, so my brother got his own room and I had to share with my little sister. Nine years later the last member of the family was born, another kid sister. Therefore, I ended up with two roommates. I wanted my own bedroom so bad that I was always complaining to my parents about how 15 years old girls should have their own bedroom. Finally, we all moved into a five-bedroom house, and I finally got my own room.   Ã‚  Ã‚  Ã‚  Ã‚  If I close my eyes, I can still remember every detail of my bedroom. My bedroom was in the shape of a perfect little square. The door was in the left side of the room facing the window. Looking in the bedroom from the door, I see my bed placed against the wall in the right side of the room, with my mirror drawer facing the bed, leaving the window in between them. My closet was behind the opened door, which was very small. I did not like having too many things in my room; it was later that I added a desk to hold my television and radio. I placed the desk against the wall in front of the bed. My mother used to put light colored curtains on the window because I loved the way the sun shined through them and it added more meaning into the room. The smell of Sunflowers perfume always takes me back to my first bedroom. I used to wear that perfume all the time because it blended right in with the settings of the room. Every morning I used to open the window and immediatel y smelled the pear tree blocked my window with its leaves. Felling the breeze of the tree through my window was very relaxing. I used to spend a long time sitting by the window looking down at the neighbor’s kids running around.

The International Baccalaureate Program Education Essay

Education and life of the twenty-first Century in an interdependent and globalized universe require an ability to believe critically and to hold an internationally orientative believing – is that pupils learn to understand the International Baccalaureate Program. Campaigners for the International Baccalaureate Diploma in the last two old ages of high school take six IB classes.A In add-on, they must run into the demands of International Baccalaureate CORE, which include: Theory of Knowledge class, composing an drawn-out essay of 4,000 words and the testing of 150 hours of preparation services. International Baccalaureate Diploma Programme is a 2 twelvemonth educational plan. It is created for the pupils aged 16 – 19, and it provides an internationally recognized making for entry into higher instruction. This programme is besides recognized by universities around the universe. International Baccalaureate Diploma Programme is administered by the International Baccalaureate and it is taught in one of three linguistic communications – English, Gallic or Spanish. If pupils want to take part in International Baccalaureate Diploma Programme, pupils must go to International Baccalaureate School. International Baccalaureate Diploma Programme pupils complete appraisal in six topics. Although the International Baccalaureate encourages pupils to prosecute the full sheepskin, International Baccalaureate significant load requires a batch of committednesss and enterprises, If they want to but pupils may take to register one or more separate entities International Baccalaure ate without basic demands. Such pupils will non have the full sheepskin. The International Baccalaureate plan is unfastened to any pupil who wishes to have International Baccalaureate Diploma or Certificate. Contentss page Abstract 2 Introduction 4 Body 6 Decision 12 Mentions and bibliography 14 Introduction Educational Program International Baccalaureate ( International Baccalaureate ) was founded in Switzerland in the late 60-ies as a cosmopolitan school plan with a common course of study that would let schools in one state to see instruction received in another state, tantamount to the national.A As the distribution of the plan IB Diploma ( alleged sheepskin IB, in fact – certification of school ) have come to acknowledge the taking universities in the world.A Now in the USA, Canada, Ireland, Great Britain, Belgium, France, Norway, Sweden and some other states, pupils with such attestations shall take into universities without entryway examinations.A Today Programme International Baccalaureate can larn from school in 1020 100 countries.A The fastest turning figure of schools in the U.S.A As a regulation, in all states schools, practicians trained in this theoretical account, are among the best.A This means, that the degree of secondary instruction provided in schools IB, above the national standard.A The IB plan exists to give pupils the cognition and accomplishments needed in life to everyone, irrespective of profession, every bit good as the accomplishments of societal adaptation.A Within the model of primary accent on academic accomplishments, the ability to believe critically, independent work skills.A Through this attack, the pupils increased motive and involvement in cognition, and therefore performance.A The IB plan is designed for two years.A The specific course of study may change from school to school, but in general is as follows.A Education is one of the three working linguistic communications of the IB: English, Gallic or Spanish ( but may be learning their native linguistic communication, native and universe literature in the national linguistic communication ) .A The footing of the plan – the survey of six topics that a pupil chooses.A Subjects of the plan are taught at two degrees: â€Å" advanced † ( Higher degree ) and â€Å" standard † ( Standard degree ) .A The first involves the scrutiny of subject in the sum of 240 preparation hours, the 2nd – 150 hours.A In the â€Å" advanced † degree study three or four topics, as a regulation necessary for him to acquire into college. The Extended Essay, which is a compulsory nucleus constituent for the International Baccalaureate Diploma ProgrammeA ( IBDP ) , is a research paper that gives pupils the chance to to carry on independent research or probe on a subject that involvements them. The Extended Essay demands a batch of creativeness and ain involvement during creative activity of the essay on the subject that is the most of import for the individual. The Extended Essay is a really utile constituent of the International Baccalaureate, because it prepares pupils to go competitory in our ambitious universe. An drawn-out essay is utile for the pupils because in some manner it can assist develop new accomplishments and to open possibilities and generate thoughts. Writing an drawn-out essay helps pupils to happen out about themselves, research something they have of all time wanted and to look into on a subject that has been interesting to them. The intent of the drawn-out essay, to give pupils an chance to: aˆ? carry oning independent research on the subject focal point ; aˆ? development of scientific research and communicating accomplishments ; aˆ? developing accomplishments of originative and critical thought ; aˆ? engagement in a systematic procedure of research related to the subject ; aˆ? Experience exhilaration of rational find. Education and life of the twenty-first Century in an interdependent and globalized universe require an ability to believe critically and to hold an internationally orientative believing – is that pupils learn to understand the International Baccalaureate Program. Campaigners for the IB Diploma in the last two old ages of high school take six IB classes.A In add-on, they must run into the demands of IB CORE, which include: Theory of Knowledge class, to compose an drawn-out essay of 4,000 words and trial of 150 hours of preparation services throughout the ( CAS ) . The Extended Essay, which is a compulsory nucleus constituent for the International Baccalaureate Diploma ProgrammeA ( IBDP ) , is a research paper that gives pupils the chance to carry on independent research or probe on a subject that involvements them. The Extended Essay demands a batch of creativeness and ain involvement during creative activity of the essay on the subject that is the most of import for the individual. The Extended Essay is a really utile constituent of the International Baccalaureate, because it prepares pupils to go competitory in our ambitious universe. The Extended Essay gives the pupil an chance to research an academic subject in deepness, doing it among the most valued constituents of the IB course of study. With the Extended Essay, every pupil has the chance to look into a subject of his specific involvement. IB – a plan for two old ages, after which pupils receive the IB International Baccalaureate which is recognized and accepted by universities in the UK and other countries.A Courses at the IB plan are offered in 40 public and private schools and colleges in the UK and besides in 930 schools and colleges in 105 countries.A International Baccalaureate plan can be an attractive option to A-level plan for academically gifted pupils who are looking for a more complete, complex and interesting curriculum.A It includes linguistic communications, mathematics, humanistic disciplines and natural scientific disciplines, originative things. Students perform supervisory work in the procedure of acquisition, and at the terminal of the program.A These trial documents are checked by testers of IB plans around the universe. Grades for each category ranged from 1 to 7.A Students who have received a sum of 24 to 45 points, are entitled to have IB Diploma.A The programme is hard and interesting for both pupils and instructors. This complex and interesting plan requires the full committedness of motivated pupils and teachers.A Schools are required to continuously re-evaluation and betterment, utilizing the criterions and guidelines used by all IB schools in the world.A Besides, pupils must go through strong comprehensive classs: A Theory of Knowledge ( TOK ) – â€Å" The Theory of Knowledge † .A This class of philosophical program, a kind of theory of research, methods and theoretical accounts of comprehension of the new.A In short, these lessons are taught to larn and non afraid to reason in the hunt for truth, here gives a base for learning.A The class besides teaches pupils to compose an essay to reason his point of position, to give definitions and formulate hypotheses, intelligently discuss.A Creativity, Action, Service ( CAS ) – â€Å" Creativity, action, service † .A Creativity may include release of the school newspaper, composing a book for the Christmas tree, etc.A Action – is a athletics, dancing – in short, all the nomadic activities.A Serving the community – is any activity aimed to assist the disadvantaged, protecting the environment etc.A – From kids ‘s places to assist in the building of the church.A Participating in theatre, athleticss, societal work contributed to the fact that non merely uncover their endowments, but besides develop of import qualities such as heed, caring about others and ability to work in a team.A By the terminal of the plan, each pupil must compose a alleged â€Å" elaborate essay † ( Extended Essay ) sum of at least 4000 words.A This must be the kind of record of the self-conducted research on a chosen subject, which is performed under the counsel of a teacher.A This enables pupils to get the accomplishments of research.A One major difference between the plan IB – is first and foremost, the attack to the survey of the subject.A Typically, in IB plan used different methods of analysis, accent on composing research documents and an independent experimental activities of students.A To acquire the Diploma Programme International Baccalaureate, a pupil must finish the plan and carry throughing all demands: base on balls an scrutiny in all six topics ( three topics at advanced degree and in three topics at standard degree ) , write the Extended Essay, and two ofA on Theory of Knowledge, work out at least 150 hours on the plan Creativity, Action, Service completed and all undertakings and mini-projects.A Each twelvemonth about 30,000 pupils receive the IB. The Extended Essay besides gives the pupil an chance to research an academic subject in deepness, doing it among the most valued constituents of the IB course of study. With the Extended Essay, every pupil has the chance to look into a subject of his ain involvement. The IB plan is unfastened to any pupil who wishes to have IB Diploma or Certificate. Teachers IB plans are invariably subjected to analysis and seek to better their instruction process.A The instructors are IB World schools have entree to the preparation centre on the Internet. The Center provides certification on the plan, illustrations of pupil work, and besides serves as an international centre of communicating for instructors program.A They may confer with with other instructors in IB schools around the universe and put their ain development as illustrations for other instructors. Capable Area -the essay capable country is chosen by the pupil. These topics are: English/Literature History Politicss Biology Mathematics Psychology Chemistry Music Theater Arts Economicss Peace & A ; Conflict Studies Visual Humanistic disciplines Environmental Systems Philosophy World Religions Geography Physicss An drawn-out essay is utile for the pupils because in some manner it can assist develop new accomplishments and to open possibilities and generate thoughts. This is a really interesting experience, because the subjects pupils are composing are of their involvement and it is ever a joy to make what you like and to speak about what is interesting for a individual. Writing an drawn-out essay helps pupils to happen out about themselves, research something they have of all time wanted and to look into on a subject that has been interesting to them. The intent of the drawn-out essay, to give pupils an chance to: aˆ? carry oning independent research on the subject focal point ; aˆ? development of scientific research and communicating accomplishments ; aˆ? developing accomplishments of originative and critical thought ; aˆ? engagement in a systematic procedure of research related to the subject ; aˆ? Experience exhilaration of rational find. The IB plan is unfastened to any pupil who wishes to have IB Diploma or Certificate. Campaigners for the full IB Diploma will utilize the drawn-out essay or undertaking in the CAS as their undertaking seminar senior students SSE. Most pupils IB plan participate in assorted Sessionss during school hours, in the early phases of recognizing the importance of precedences which are set and non detaining instances until subsequently. Upon completion of the plan, pupils will get: ability to believe international classs, finely honed accomplishments of critical thought, assurance in all their academic enterprises. Besides, pupils will larn: conducting independent research, composing essays for college degree, critical analysis of information, taking the context of reading, rules of effectual acquisition, readying of the balanced agenda. And pupils frequently receive: penchant for admittance to college, loans for College, admittance to the plan increased, preparation, scholarships. All Advanced Features external rating experts IBO.A There are general standards for rating. And it is used to find the essay score.A The chief standards relate to general facets of the essays, such as letters, usage of the informations and general idea.A Subject standards are concerned about how to take the subject direction in the context of chosen subject in the essay.A Official guidelines for essays will be given to a pupil, when the subject of an essay will non be completed. The classs of the mark of the essay: A first-class B good C satisfactory D mediocre E simple By the terminal of the International Baccalaureate plan, each pupil must compose a alleged â€Å" elaborate essay † ( Extended Essay ) sum of at least 4000 words.A This must be the kind of record of the self-conducted research on a chosen subject, which is performed under the counsel of a teacher.A This enables pupils to get the accomplishments of research.A Every twelvemonth about 30,000 pupils receive the International Baccalaureate Diploma.A For diploma International Baccalaureate a pupil should: A -successfully pass the tests in all six topics ( three topics at advanced degree and three -subjects at standard degree ) ; A -write â€Å" elaborate essay † ( Extended Essay ) A ; -write two documents on the Theory of Knowledge ( TOK ) A ; -work out at least 150 hours of plan Creativity, Action, Service ( CAS ) A ; -complete all undertakings and mini-projects. Theory of Knowledge class gives pupils a possibility to make and believe about cognition, to believe about larning in all topics they learn in the class of Diploma Programme, and to set up links between academic fields.A Advanced essay, much of the missive to 4000 words, and it enables pupils to research subjects of their specific involvement, which they can choose.A It helps pupils to utilize their creativeness and thoughts, every bit good as imaginativeness and besides to develop accomplishments of independent research, which should be at the university. Diploma Programme aims to develop pupils ‘ cognition and accomplishments and besides they will necessitate to execute undertakings IBO, as outlined in the statement of the organisation ‘s mission and pupil profile. Teaching and acquisition in the Diploma Programme aid to show world in the mundane pattern of educational doctrine of the organisation. Extended essays in the doctrine give pupils the chance to look into the philosophical subjects of particular interest.A The pupil is invited to come in into serious, personal ideas, develop and learn in a disciplined and originative manner specific philosophical questions.A Chosen subject can be supported, for illustration, work done in category, current events on issues associating to modern-day argument, treatment, single reading and / or contemplation, or conceptual characteristics of belief systems that have non antecedently encountered by the student.A It is bounded that the subject should be chosen so that it can be considered carefully.A For illustration, in May, it is preferred to take as a starting point, specific hypotheses, instead than general, some of the thoughts of a philosopher, non a few, or one text, the philosopher, but non all of his or her work. Counter-claims and expostulations must be provided, to see and, if possible, refuted.A Although it is inappropriate to be avoided, the wider deductions of philosophical inquiries should research the appropriate grade and consciousness must be clear links between these issues and more planetary jobs of human life. Of peculiar note is the flexibleness of the program.A Every three old ages, amended.A On bettering the classs are invariably working profile commissions of teachers.A Thus, International Baccalaureate – a various plan that combines the really best that exists in school instruction in different countries.A This is a cosmopolitan linguistic communication that is apprehensible to about any university or college. However, the International Baccalaureate sheepskin receive merely those on the test in the sum scored at least 24 points ( scrutinies – 6, the highest mark – 7, the lowest – 1, 3 more points available for the thesis, and engagement in the competition CAS ) .A Cope with this undertaking is non all: for the universe statistics, around 30 % of pupils who completed the class, remain without a diploma.A International Baccalaureate sheepskin is extremely valued for their objectiveness, because in add-on to internal rating, which exposes the school instructors, the pupil receives and external appraisal, which exhibited abroad tester One trial centre in the UK International Baccalaureate – a cosmopolitan plan, which incorporated all the mostA the best that exists in school instruction in different countries.A This is a cosmopolitan linguistic communication that is apprehensible to about any university or college.DecisionEducation and life of the twenty-first Centu ry in an interdependent and globalized universe require an ability to believe critically and creatively, to hold an internationally orientative believing – is that pupils learn to understand the International Baccalaureate Program ( IB ) , and it is unfastened to any pupil who wishes to have IB Diploma or Certificate. Campaigners for the IB Diploma in the last two old ages of high school take six IB classes.A And besides they must run into the demands of IB CORE, which include: Theory of Knowledge class, an drawn-out essay of 4,000 words and the testing of 150 hours of preparation services throughout the ( CAS ) . Extended essays in the doctrine ever give pupils an chance to look into the philosophical subjects of their interest.A Students are invited to believe creatively, develop and larn in a disciplined and originative manner of specific philosophical inquiry, it is appropriate to this issue and come to a clear conclusion.A Chosen subject can be supported, for illustration, work done in category to current events on issues associating to modern-day argument, treatment, single reading and / or contemplation, or conceptual characteristics of belief systems that have non antecedently encountered by the pupil. To go an International Baccalaureate, an educational establishment has to get down application procedure. Besides, during that period instructors have preparations in the International Baccalaureate. After application procedure, International Baccalaureate there is authorization.A Equally shortly as school is authorized to offer the International Baccalaureate, so one-year fee gives the warrant to expose the International Baccalaureate logo, entree to Online Curriculum Centre, support from the International Baccalaureate and besides entree to International Baccalaureate Information System.A Online Curriculum Centre besides provides information, resources and support for International Baccalaureate coordinators and instructors. International Baccalaureate Information System is a database, used by International Baccalaureate coordinators.A IB – a plan for two old ages, after which pupils receive the International Baccalaureate, which is recognized and accepted by universities in the UK and other countries.A Courses at the IB plan are offered in 40 public and private schools and colleges in the UK and besides in 930 schools and colleges in 105 countries.A As the distribution of the plan IB Diploma ( alleged sheepskin IB, in fact – certification of school ) have come to acknowledge the taking universities in the world.A Now in the USA, Canada, Ireland, Great Britain, Belgium, France, Norway, Sweden and some other states, pupils with such attestations shall take into universities without entryway examinations.A Today Programme International Baccalaureate can larn from school in 1020 100 countries.A The fastest turning figure of schools in the U.S..A As a regulation, in all states schools, practicians trained in this theoretical account, are among the best.A This means, that the degree of secondary instruction provided in schools IB, above the national standard.A The IB plan exists to give pupils the cognition and accomplishments, really utile in life to everyone, irrespective of profession, every bit good as the accomplishments of societal adaptation.A Within the model of primary accent on academic accomplishments, the ability to believe critically, independent work accomplishments.